肯尼迪于1961年1月20日正式宣誓就任美国第三十五任总统，他在就职演说中对国际事物给予了极大关注。他呼吁美国民众承担起更多的义务，做出更大的牺牲。肯尼迪的就职演说与富兰克林·德拉诺·罗斯福的第一次就职演说被并称为20世纪最令人难忘的两次美国总统就职演说。
First Inaugural Address 肯尼迪总统就职演说

We observe today not a victory of party, but a celebration of freedom, symbolizing an end, as well as a beginning; signifying renewal, as well as change. For I have sworn before you and Almighty God the same solemn oath our forebears prescribed nearly a century and three quarters ago.

今天我们庆祝的不是政党的胜利，而是自由的胜利。这象征着一个结束，也象征着一个开端；意味着延续也意味看变革。因为我已在你们和全能的上帝面前，宣读了我们的先辈在170多年前拟定的庄严誓言。

In your hands, my fellow citizens, more than in mine, will rest the final success or failure of our course. Since this country was founded, each generation of Americans has been summoned to give testimony to its national loyalty. The graves of young Americans who answered the call to service surround the globe.

公民们，我们方针的最终成败与其说掌握在我手中，不如说掌握在你们手中。自从合众国建立以来，每一代美国人都曾受到召唤去证明他们对国家的忠诚。响应召唤而献身的美国青年的坟墓遍及全球。

Now the trumpet summons us again, not as a call to bear arms, though arms we need; not as a call to battle, though embattled we are; but a call to bear the burden of a long twilight struggle, year in and year out, "rejoicing in hope; patient in tribulation"，a struggle against the common enemies of man: tyranny, poverty, disease, and war itself.

现在，号角已再次吹响---不是召唤我们拿起武器，虽然我们需要武器；不是召唤我们去作战，虽然我们严阵以待。它召唤我们为迎接黎明而肩负起漫长斗争的重任，年复一年，从希望中得到欢乐，在磨难中保持耐性，对付人类共同的敌人---专制、社团、疾病和战争本身。

Can we forge against these enemies a grand and global alliance, North and South, East and West, that can assure a more fruitful life for all mankind? Will you join in that historic effort?

为反对这些敌人，确保人类更为丰裕的生活，我们能够组成一个包括东西南北各方的全球大联盟吗？你们愿意参加这一历史性的努力吗？

In the long history of the world, only a few generations have been granted the role of defending freedom in its hour of maximum danger. I do not shrink from this responsibility. I welcome it. I do not believe that any of us would exchange places with any other people or any other generation. The energy, the faith, the devotion which we bring to this endeavor will light our country and all who serve it. And the glow from that fire can truly light the world.

在漫长的世界历史中，只有少数几代人在自由处于最危急的时刻被赋予保卫自由的责任。我不会推卸这一责任，我欢迎这一责任。我不相信我们中间有人想同其他人或其他时代的人交换位置。我们为这一努力所奉献的精力、信念和忠诚，将照亮我们的国家和所有为国效劳的人，而这火焰发出的光芒定能照亮全世界。

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