Make a difference 是指会对现有的情况造成差别，跟以往不同。

A：I know you need some financial help.

If I give you a raise, will it help?

我知道你需要一些经济支援。

我给你加薪会有帮助吗？

B：Well, it will certainly make a difference.

这将会大有帮助。

Make a difference 也可以指对于现状有所不满，希望未来能使大环境产生变化。
A：What do you want to do with your job?

你这一生要做什么？
B：I want to be a nurse so that I can make a difference.

我要当护士让自己力挽狂澜。

1、 Read someone like an open book 看穿某人的心思

A：You and Sara seem to make a good couple.

你和萨拉真是天生一对。
B：Yeah. She reads me like an open book.

对啊。她能看穿我的心思。

2、 Paint the town red 尽情享受夜生活

A：What are you going to do in New York?

你在纽约要干吗？
B：Paint the town red, of course!

夜夜笙歌，这还用问！